When you’re taking statins for top ldl cholesterol, you’ll have encountered associates or household (or social media commenters) who level out a possible hyperlink to dementia. It’s sufficient to make anybody pause. There’s quite a lot of confusion across the matter of ldl cholesterol medicines and cognition. For one, coronary heart and mind well being are sometimes carefully intertwined, and people who take statins could already be in danger for points like reminiscence loss. Right here, we requested medical doctors to clarify the connection between statins and dementia—spoiler alert: they could really scale back your threat of cognitive impairment—plus extra methods to maintain your thoughts sharp.
The hyperlink between statins and dementia
Taking statins to scale back excessive levels of cholesterol can also be necessary for lowering your threat of vascular dementia in addition to coronary heart assault and stroke threat.
“They are protective against one of the more devastating types of dementia, which is the type of dementia caused by stroke,” says Logan DuBose, MD, a doctor and co-founder of Olera who writes about dementia, Alzheimer’s, and different age-related situations. “This can be prevented by protection against atherosclerosis of the microvascular and vascular system, which is what statins do.”
The confusion round this matter could come from earlier research that time to a possible hyperlink. As an example, individuals who began taking statins had a better chance of being identified with sudden reminiscence loss inside 30 days than those that didn’t take any cholesterol-lowering medicine in a 2017 examine printed in JAMA Inner Medication. Nevertheless, these taking non-statin ldl cholesterol medicine had the identical hyperlink, which means the impact wasn’t particular to statins.
The U.S. Meals & Drug Administration has taken the stance that statins hardly ever trigger any type of cognitive unwanted effects that aren’t resolved by stopping statins. What’s extra, these potential reminiscence issues additionally look like reversible in lots of instances.
“Although a few studies have raised concerns that statins could actually cause memory problems, these cases appear to be rare, and memory often improves after stopping the drug,” says David Perlmutter, MD, a doctor and board-certified neurologist.
Needless to say in case your coronary heart is wholesome, your mind doubtless can be too. Nevertheless, this could possibly be one more reason for the confusion round statins and dementia.
“People on statins often have other health problems, like high blood pressure or diabetes, that can also negatively affect the brain,” says Dr. Perlmutter. “So it’s hard to separate the effects of the statin from the effects of the underlying health issue.”
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Specialists say you must proceed to take statins as prescribed
“Research has shown that a small number of people may experience memory side effects from lipophilic statins like atorvastatin or simvastatin, but this very minor and slightly theoretical risk should not be confused with significant dementia risk,” says Dr. DuBose.
Plus, one yr of statin use was really linked to a 20 % lower in dementia threat in a 2018 meta-analysis of 31 research printed within the journal Medication.
A 2025 meta-analysis in Translational Analysis & Scientific Interventions echoed these findings—individuals who took statins had a decrease threat of growing dementia than those that didn’t, with advantages notably robust in individuals with kind 2 diabetes, those that took statins for greater than three years and Asian populations. The remedy rosuvastatin (model title Crestor) confirmed the strongest protecting impact.
“Overall, the evidence does not support the idea that statins cause dementia,” says Dr. Perlmutter. And in reality, it might even decrease your threat.
Extra methods statin customers can scale back their dementia threat
When you’re taking a statin and need to lower your threat of dementia additional, making just a few easy life-style modifications can have the most important influence. Right here’s what our consultants suggest to guard your cognitive functioning over time:
Comply with a Mediterranean weight-reduction plan
This consuming plan is wealthy in nuts, berries, greens and fish. “It helps maintain good cholesterol and lowers bad cholesterol, and has been shown to be protective against cerebrovascular damage, which is protective against dementia,” says Dr. DuBose.
Take a brisk stroll
Train doesn’t imply you need to hit the heavy weights on the gymnasium. “Low-intensity, anaerobic exercise like swimming and speed walking are ideal for people of all ages to increase blood flow and increase muscle and bone health, which will be important for mobility in older age and can be protective against dementia,” says Dr. DuBose.
Meet up with associates
Make investments deeply in your folks, household and hobbies with these you like. “This is critical for building a positive cognitive reserve and a meaningful life now and in the future,” says Dr. DuBose. “It protects against rapid negative cognitive decline. And people who have meaningful relationships cultivated over a lifetime have a more pleasant experience in older age, even if dementia sets in.”
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Which statins could also be higher for mind well being?
When you’re nonetheless involved concerning the potential threat of statins and dementia, ask your physician about hydrophilic statins, like pravastatin and rosuvastatin. “These do not cross the blood-brain barrier and may theoretically be better for someone concerned with statin-induced memory side effects,” says Dr. DuBose.
However once more: The advantages of statins to lower coronary heart assault, stroke and vascular dementia threat clearly outweigh the dangers. “In general, the risk of taking a statin and having any memory-related side effects or increasing dementia risk is very low and should not persuade somebody from using it,” provides Dr. DuBose.
Extra on mind well being and dementia:
Forgetfulness Vs. Dementia: The way to Inform if It’s Regular Getting older or One thing Extra Critical
Specialists Reveal 4 Easy Hobbies That Might Lower Dementia Danger and Increase Your Reminiscence
The way to Cease Mind Getting older With Straightforward, Stress-Lowering Habits
This content material is just not an alternative to skilled medical recommendation or prognosis. At all times seek the advice of your doctor earlier than pursuing any therapy plan.
